Features of Enskyia
Enskyia is a therapeutic medication used to improve symptoms of erectile dysfunction (ED).

This product contains the same active ingredient as the globally renowned Viagra, characterized by its light red oval-shaped tablets.

Efficacy of Enskyia
The main component, Sildenafil, inhibits the action of phosphodiesterase-5 (PDE-5), which impedes erectile function.

PDE-5 enzyme breaks down cyclic guanosine monophosphate (cGMP), essential for erection.

The breakdown of cGMP results in the inability to achieve an erection, a condition known as erectile dysfunction (ED).

Sildenafil inhibits the PDE-5 enzyme, effectively dilating blood vessels in the penis and relaxing smooth muscles in the penile corpus cavernosum.

This action allows for blood vessel dilation and muscle relaxation, thereby promoting significant blood flow into the penile corpus cavernosum, facilitating an erection.

Duration of Enskyia's Effects
While the effects last for 4-6 hours, it's important to note that the medication does not automatically induce an erection; sexual stimulation or arousal is required to trigger the erectile response.

Dosage and Strength of Enskyia
This product has not yet received official approval, but through our personal import service, you can purchase 50mg or 100mg tablets.

First-time users are advised to start with half a tablet, using a pill cutter for precise dosing.

Additional Information
While maintaining efficacy equivalent to Viagra, this product offers a more affordable price, making it an excellent value.

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References
In addition to referencing the original product's instructions, this product description also draws from the following sources:
・Sildenafil - Wikipedia

Timing of Administration
The correct way to take Ensugia is to consume it on an empty stomach, 1 hour before sexual activity.

After the first dose, wait at least 24 hours before the next administration.

Recommended Dosage
Ensugia sold on this site comes in 100mg tablets, which can be split into 50mg doses using a pill cutter.

If 50mg shows insufficient effect, the dose may be increased to 100mg. Adjust according to individual needs.

Some users take 2-3 times the recommended dose for stronger effects, but this does not enhance efficacy.

The maximum dose per sexual encounter is 100mg.

For individuals with smaller builds, 25mg/50mg may suffice.

Ensugia containing 100mg of active ingredient is more suitable for larger men.

Recommended Initial Dose
When taking sildenafil (the main component of Ensugia) for the first time, start with 25mg.

Food Interactions
Avoid eating for at least 2 hours before taking the medication.

This relates to the absorption process of sildenafil: the component needs to be absorbed through the intestines into the bloodstream.

If food is present in the stomach, the tablet may be absorbed by the stomach before reaching the intestines.

Additionally, consuming high-fat meals before taking the medication may cause fats to coat the intestinal walls, hindering drug absorption.

Poor absorption will prevent the medication from working effectively, so always take it on an empty stomach.

Food can be consumed 30 minutes after taking the medication, as absorption is complete by then.

Alcohol Interactions
Although it can be taken with alcohol, the vasodilating effect may accelerate intoxication, so avoid excessive drinking.

Contraindications
・Patients with cardiovascular diseases (those not suitable for sexual activity)

・Individuals with severe liver dysfunction

・Patients with hypotension or uncontrolled hypertension

・Those with a history of stroke, cerebral hemorrhage, or myocardial infarction within the past 6 months

※Always consult a doctor before use

Primary Side Effects
The main side effects include decreased blood pressure due to vasodilation, eye congestion, facial flushing, palpitations, nasal congestion, etc.

These symptoms are considered to be caused by vasodilatory effects and may alleviate when increased sexual desire promotes greater blood flow to the penis.

Special Symptoms
Special symptoms such as visual abnormalities may occur, including a bluish tint in vision (as if wearing blue glasses) or difficulty distinguishing between blue and green hues.

In most cases, these are temporary phenomena that do not require concern. However, if significant vision loss occurs, there is a risk of non-arteritic anterior ischemic optic neuropathy (NAION).

If sudden vision deterioration or loss occurs, immediately consult an ophthalmologist.

Additionally, if an erection accompanied by pain persists for more than 4 hours, there may be a risk of priapism (persistent erection).

If an erection lasts longer than 4 hours, seek immediate medical attention.

※What is non-arteritic anterior ischemic optic neuropathy (NAION)?
This is a condition where blood supply to the optic nerve is interrupted, leading to dysfunction or necrosis of optic nerve cells.

This state is referred to as ischemic optic neuropathy.

Although the causal relationship remains unclear, studies suggest a certain correlation with the use of ED treatment medications (occurrence is extremely rare).

※What is priapism (persistent erection)?
Priapism (also known as persistent erection) refers to a condition where the penis cannot return to a normal state or has difficulty recovering after erection.

This condition is also known as penile rigidity.

The primary cause is believed to be dysfunction in the arterial system within the corpora cavernosa of the penis.

If an erection does not subside naturally and persists for more than 4 hours, seek immediate medical treatment.

Contraindicated Concomitant Medications
Contraindicated concomitant medications are those that must not be taken together with Enthusia due to potential interactions.

・Nitrate drugs and NO donor drugs
(Nitroglycerin, Amyl Nitrite, Isosorbide Dinitrate)
Concomitant use may enhance hypotensive effects.

・Amiodarone Hydrochloride
(Ancarone Tablets)
Concomitant use may exacerbate QTc prolongation caused by amiodarone hydrochloride.

Precautions for Concomitant Use
Precautions for concomitant use refer to medications that require special attention when taken with Enthusia.

・Grapefruit (including juice)
Its furanocoumarin content inhibits metabolic enzyme activity, slowing drug breakdown.
This may lead to excessive absorption of drug components, enhancing efficacy or worsening side effects.

・CYP3A4 inhibitors/inducers
Ritonavir, Saquinavir, Darunavir

・Antihypertensive drugs
As Enthusia has hypotensive effects, concomitant use with antihypertensives may cause temporary dizziness, vertigo, or other low blood pressure symptoms.

・Store in a cool place away from direct sunlight and low humidity.

・Keep out of reach of children.

・Do not transfer to other containers to prevent accidental ingestion and maintain product quality.

・When using individually packaged medications multiple times, store with minimal air exposure and consume within 2 days after opening.

・Do not ingest or use products past their labeled expiration date.

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